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Androgel (Cernos Gel)
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Androgel (Cernos Gel)
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Androgel (Cernos Gel) 50mg 7sachets 7 sachets
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Androgel (Cernos Gel)
Androgel Generic (Testosterone) 1.62%
Androgel Generic (Testosterone) 1.62% is an androgenic agent containing testosterone. In men, it stimulates the development of the genital organs and the prostate gland. It affects the development of secondary sexual characteristics in men, increases libido and potency, and through the central nervous system affects sexual behavior. It also reduces fat deposition. Testosterone does not affect the development of the testicles but inhibits the secretion of gonadotropins (LH and FSH) by the pituitary gland.
It has an anabolic effect: it increases muscle mass by retaining nitrogen, sulfur, sodium, phosphorus, K+, and water in the body, which are necessary for protein synthesis. The effects of testosterone manifest themselves after converting it to estradiol, which subsequently binds to receptors of target organs (Leydig’s testicular cells, pituitary, brain, adipose tissue).
Pharmacokinetics
After applying Androgel Generic (Testosterone) 1.62% on the skin, 14% of the dose is absorbed, and testosterone enters the bloodstream within 24 hours.
The concentration of testosterone reaches a constant value after the second day of treatment. It is essential that daily variations in intensity are the same as endogenous testosterone. With this route of administration, there are no peaks of testosterone in the blood, which occur when injected. External use of the drug is not accompanied by an increase in steroids in the liver, as in oral testosterone therapy, which is higher than physiological norms.
After cessation of treatment, the level of testosterone begins to decrease a day after the last dose and reaches its initial level in 3-4 days.
Active metabolites of testosterone (dihydrotestosterone, estradiol) are excreted in urine and feces.
Contraindications
- Hypersensitivity to testosterone
- Prostate cancer
- Malignant neoplasms
- Other localization
- Severe heart failure
- Liver and kidney failure
- Epilepsy
- Arterial hypertension
- Experience with children is absent